Another uncapped player, fullback Geoffrey Palis, will also start as Brunel will look to restore France's confidence for his first game in charge.
What are the match odds?
France were accused of abusing the HIA system after snatching a late victory over Wales past year.
France meanwhile are on a seven-game losing streak, reflected in the home side's 5/2 odds.
It was an incredible finish but it should not completely gloss over what threatened to be a major controversy with France once again accused of manipulating the Head Injury Assessment protocols, just as they were in that infamous 100-minute match against Wales previous year when they brought Rabah Slimani back on for Uini Atonio despite the latter appearing to have no idea why he was going off.
A draw is priced at 25/1.
When asked what he thought of before kicking the winning goal, the fly-half said: "I went back to many years ago when we played Treviso away and I was in an nearly identical position and just flashed back to that".
Jacob Stockdale, Bundee Aki and James Ryan made their first Six Nations appearances for Ireland.
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